New fight over fetal tissue grafts.
نویسنده
چکیده
John Abelson Frederick W. Alt Don L. Anderson Michael Ashburner Stephen J. Benkovic David E. Bloom Floyd E. Bloom Piet Borst Michael S. Brown Henry R. Bourne James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Paul J. Crutzen Robert Desimone Nicole Le Douarin Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard K. Friedrich Theodore H. Geballe Margaret J. Geller John C. Gerhart Roger 1. M. Glass Stephen P. Goff Peter N. Goodfellow Corey S. Goodman Stephen J. Gould ira Herskowitz Eric F. Johnson Stephen M. Kosslyn Michael LaBarbera Charles S. Levings Ill Alexander Levitzki Harvey F. Lodish Richard Losick Diane Mathis Anthony R. Means Shigetada Nakanishi Roger A. Nicoll William H. OrmeJohnson i11 Stuart L. Pimm Yeshayau Pocker Dennis A. Powers Ralph S. Quatrano V. Ramanathan Douglas C. Rees T. M. Rice Erkki Ruoslahti David C. Rubie Gottfried Schatz Jozef Schell Ronald H. Schwartz Terrence J. Sejnowski Ellen Solomon Thomas A. Steitz Michael P. Stryker Richard F. Thompson Robert T. N. Tjian Emil R. Unanue Geerat J. Vermeij Bert Vogelstein Harold Weintraub Zena Werb George M. Whitesides Owen N. Witte William A. Wuif Keith Yamamoto
منابع مشابه
Neurobiology of Disease Serotonin Neuron Transplants Exacerbate L-DOPA- Induced Dyskinesias in a Rat Model of Parkinson’s Disease
Clinical trials in patients with Parkinson’s disease have shown that transplants of fetal mesencephalic dopamine neurons can form a new functional innervation of the host striatum, but the clinical benefits have been highly variable: some patients have shown substantial recovery in motor function, whereas others have shown no improvement and even a worsening in the 3,4-dihydroxyphenyl-L-alanine...
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Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [F]6-flurorol-3,4-dihydroxyphenylalanine (F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understand morphological and neurochemical alterations of grafted neurons, we performed postmor...
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Animal studies demonstrate that the fetus heals cutaneous wounds by reformation of normal tissue architecture without scar formation. We have developed a new model to study human fetal skin wound healing. Grafts of human fetal skin placed onto athymic mice retain the morphologic features of normal development, although they differentiate at an accelerated rate when placed cutaneously compared t...
متن کاملSurvival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts.
BACKGROUND Cardiomyocyte grafting augments myocyte numbers in the heart. We investigated (1) how developmental stage influences graft survival; (2) whether acutely necrotic or healing cardiac lesions support grafts; and (3) the differentiation and integration of cardiomyocyte grafts in injured hearts. METHODS AND RESULTS Cardiomyocytes from fetal, neonatal, or adult inbred rats were grafted i...
متن کاملSerotonin Axons Lose the Ability to Grow Into Fetal Ventral Mesencephalic Grafts Shortly After Birth
Adult host serotonin (5-HT) neurons display a particularly good capacity to innervate intrastriatal grafts of fetal tissue from several CNS regions /1,2/. However, following intra-striatal transplantation of ventral mesencephalic tissue, the 5-HT innervation from adult host brain was found to be very sparse and almost exclusively confined to the borders of the grafts /3/. The present study inve...
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عنوان ژورنال:
- Science
دوره 263 5147 شماره
صفحات -
تاریخ انتشار 1994